Journal article
Role of genetic factors in lower- and higher-order aberrations - The genes in myopia twin study
M Dirani, M Chamberlain, TA Couper, RH Guymer, PN Baird
Ophthalmic Research | Published : 2009
DOI: 10.1159/000209667
Abstract
Aims: We intended to investigate the relative genetic contribution in wavefront aberrations using a sub-group of twins recruited in the Genes in Myopia twin study, and subsequently provide direction for future studies into the aetiology of mono-chromatic aberrations. To our knowledge, the Genes in Myopia twin study is the first study to explore the role of genetic factors in both lower- and higher-order aberrations in a Caucasian population. Methods: Each individual completed a general questionnaire and underwent a comprehensive eye examination. Higher-order wavefront aberrations were calculated with Zernike coefficients up to the fourth order. Results: A total of 46 twin pairs with a mean a..
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Funding Acknowledgements
The authors of this study would like to acknowledge the ATR for acting as the main source for twin recruitment. They would also like to acknowledge Arthur Ho from Vision CRC for his professional advice on the statistical approach used in this paper. This research was supported by the Australian Government Cooperative Research Centre Program.