Journal article

Gemcitabine and vinorelbine combination chemotherapy for patients with advanced soft tissue sarcomas - Results of a phase II trial

Palma Dileo, Jeffrey A Morgan, David Zahrieh, Jayesh Desai, Jeanine M Salesi, David C Harrnon, M Travis Quigley, Kathleen Polson, George D Demetri, Suzanne George

CANCER | WILEY | Published : 2007


BACKGROUND: Single-agent gemcitabine and vinorelbine have activity in treatment of patients with soft-tissue sarcomas. The combination of gemcitabine plus vinorelbine has activity against several forms of metastatic carcinoma with acceptable toxicity. This study evaluated the efficacy and tolerability of gemcitabine plus vinorelbine in advanced soft-tissue sarcoma. METHODS: A single academic center performed this phase II trial. Eligible patients had unresectable or metastatic soft-tissue sarcomas, Eastern Cooperative Group performance status of 0-2, adequate organ function, and 4 months. There has been 1 CR lasting >1 year in a patient with high-grade pleomorphic spindle-cell sarcoma. CONCL..

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