Oligodendrocyte Positioning in Cerebral Cortex is Independent of Projection Neuron Layering
Seong-Seng Tan, Michael Kalloniatis, Hue-Trung Truong, Michele D Binder, Holly S Cate, Trevor J Kilpatrick, Vicki E Hammond
GLIA | WILEY-LISS | Published : 2009
The factors affecting normal oligodendrocyte positioning in the cerebral cortex are unknown. Apart from the white matter, the highest numbers of oligodendrocytes in the rodent cortex are found in Layers V/VI, where the infragranular neurons normally reside. Few, if any, oligodendrocytes are normally found in the superficial cortical layers. To test whether or not this asymmetric positioning of oligodendrocytes is linked to the lamina positions of Layer V/VI projection neurons, mutant mice that cause neuronal layer inversion were examined. In three lines of mutant mice (Reeler, disabled-1, and p35) examined, representing two different genetic signaling pathways, the oligodendrocyte distributi..View full abstract
Grant sponsors: NH&MRC, Robert G Leitl Estate.