Gut mucosal response to food antigens in Crohn's disease

Abstract

Background: Food antigens may contribute to gut inflammation in Crohn's disease. Aim: To assess in vivo sensitization to food antigens, ascertain whether sensitivity is gut specific, assess food sensitization in vitro, and correlate in vivo changes with histological and blood changes. Methods: Skin testing and rectal exposure to six food antigens (cereal, cabbage, citrus, milk, yeast and peanut) and control saline were assessed double-blind by immediate and 3.5-h laser Doppler blood flowmetry, and rectal biopsies were taken. Peripheral blood lymphocyte proliferation was measured in response to the same antigens. Results: Ten patients with Crohn's disease and 10 healthy controls were studied...