Journal article

Review article: the complexity of drug development for irritable bowel syndrome

MA Kamm

ALIMENTARY PHARMACOLOGY & THERAPEUTICS | BLACKWELL PUBLISHING LTD | Published : 2002

Abstract

Drug development for functional gastrointestinal disorders is complex. These conditions involve central and peripheral physiological changes, together with psychological factors. Methodological problems have included a poor appreciation of the physiological and psychological correlates of patients' symptoms, a lack of animal models of proven relevance, and safety issues. Government, patient pressure groups and the Internet can also influence a drug's success. Most recent interest has focused on the serotonin (5-HT) modifying drugs. Cisapride has been withdrawn in some countries because of concerns related to QT prolongation and cardiac arrhythmias. The 5-HT3 antagonists, developed to modify ..

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