Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
Gary P Anderson
The Lancet | ELSEVIER SCIENCE INC | Published : 2008
Clinical asthma is very widely assumed to be the net result of excessive inflammation driven by aberrant T-helper-2 (Th2) immunity that leads to inflamed, remodelled airways and then functional derangement that, in turn, causes symptoms. This notion of disease is actually poorly supported by data, and there are substantial discrepancies and very poor correlation between inflammation, damage, functional impairment, and degree of symptoms. Furthermore, this problem is compounded by the poor understanding of the heterogeneity of clinical disease. Failure to recognise and discover the underlying mechanisms of these major variants or endotypes of asthma is, arguably, the major intellectual limita..View full abstract
The author's research is funded by the National Health and Medical Research Council of Australia (NHMRC) via project and programme grants.