Journal article

Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome

NM Thoua, CDR Murray, WJ Winchester, AJ Roy, MCL Pitcher, MA Kamm, AV Emmanuel

Alimentary Pharmacology and Therapeutics | WILEY | Published : 2009

Abstract

BACKGROUND: Acute physical stress causes alteration in gut autonomic function and visceral hypersensitivity in patients with irritable bowel syndrome (IBS). We have developed a model to measure this stress response. AIM: To assess whether treatment with a drug effective in treating IBS (amitriptyline) alters the response to acute stress in IBS patients. METHODS: Nineteen patients with IBS were given amitriptyline 25-50 mg. Patients underwent physical stress (cold pressor) test at baseline and after 3 months of treatment. Physiological parameters measured were: stress perception; systemic autonomic tone [heart rate (HR) and blood pressure (BP)]; gut specific autonomic innervation [rectal muco..

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