Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome
NM Thoua, CDR Murray, WJ Winchester, AJ Roy, MCL Pitcher, MA Kamm, AV Emmanuel
Alimentary Pharmacology and Therapeutics | WILEY | Published : 2009
BACKGROUND: Acute physical stress causes alteration in gut autonomic function and visceral hypersensitivity in patients with irritable bowel syndrome (IBS). We have developed a model to measure this stress response. AIM: To assess whether treatment with a drug effective in treating IBS (amitriptyline) alters the response to acute stress in IBS patients. METHODS: Nineteen patients with IBS were given amitriptyline 25-50 mg. Patients underwent physical stress (cold pressor) test at baseline and after 3 months of treatment. Physiological parameters measured were: stress perception; systemic autonomic tone [heart rate (HR) and blood pressure (BP)]; gut specific autonomic innervation [rectal muco..View full abstract
Declaration of personal and funding interests: A. V. Emmanuel has received research grants from GSK, and has served on advisory boards for Takeda, Pfizer and Coloplast, and has received honoraria for lectures from Ferring, Novartis, AstraZeneca, Medtronic, and Coloplast.