Journal article
Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction
A Brémond, O Meynet, K Mahiddine, S Coito, M Tichet, K Scotlandi, JP Breittmayer, P Gounon, PA Gleeson, A Bernard, G Bernard
Blood | AMER SOC HEMATOLOGY | Published : 2009
Abstract
By presenting antigenic peptides on the cell surface, human leukocyte antigen (HLA) class I molecules are critical for immune defense. Their surface density determines, to a large extent, the level of CD8+ T cell-dependent immune reactions; their loss is a major mechanism of immune escape. Therefore, powerful processes should regulate their surface expression. Here we document the mechanisms used by CD99 to mediate HLA class I modulation. Up-regulation of HLA class I by IFN-7 requires CD99. In the trans Golgi network (TGN), and up to the cell surface, CD99 and HLA class I are physically associated via their transmembrane domain. CD99 also binds p230/ golgin-245, a coiled-coil protein that re..
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Funding Acknowledgements
This work was supported by grants from Inserm, Association pour la Recherche sur le Cancer (ARC), La Ligue contre le cancer, European project Prognosis and Therapeutic Targets in the "Ewing" Family of Tumors (PROTHETS), Institut National du Cancer (INCA) Canceropole PACA, Ministere de la Recherche et des Technologies, Fondation de France, Fondation de la Recherche Medicale (FRM), and Agence Nationale de Biomedecine.