Journal article
Positive end-expiratory pressure enhances development of a functional residual capacity in preterm rabbits ventilated from birth
ML Siew, AB Te Pas, MJ Wallace, MJ Kitchen, RA Lewis, A Fouras, CJ Morley, PG Davis, N Yagi, K Uesugi, SB Hooper
Journal of Applied Physiology | Published : 2009
Abstract
The factors regulating lung aeration and the initiation of pulmonary gas exchange at birth are largely unknown, particularly in infants born very preterm. As hydrostatic pressure gradients may play a role, we have examined the effect of a positive end-expiratory pressure (PEEP) on the spatial and temporal pattern of lung aeration in preterm rabbit pups mechanically ventilated from birth using simultaneous phase-contrast X-ray imaging and plethysmography. Preterm rabbit pups were delivered by caesarean section at 28 days of gestational age, anesthetized, intubated, and placed within a water-filled plethysmograph (head out). Pups were imaged as they were mechanically ventilated from birth with..
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Awarded by SPring-8 synchrotron facility (Japan)
Funding Acknowledgements
This research was supported by the Australian Research Council and the Australian National Health and Medical Research Council. We acknowledge financial support from the Access to Major Research Facilities Programme, which is a component of the International Science Linkages Programme established under the Australian Government's innovation statement, "Backing Australia's Ability." The authors also gratefully acknowledge the support provided by the SPring-8 synchrotron facility (Japan), which was granted by the SPring-8 Program Review Committee (proposal nos. 2006B0002, 2007A0002). A. B. te Pas is a recipient of a Ter Meulen Fund grant for working visits, Royal Netherlands Academy of Arts and Sciences, The Netherlands. M. J. Kitchen is a recipient of an Australian Research Council Post-Doctoral Fellowship.