Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs
Megan J Wallace, Megan E Probyn, Valerie A Zahra, Kelly Crossley, Timothy J Cole, Peter G Davis, Colin J Morley, Stuart B Hooper
RESPIRATORY RESEARCH | BMC | Published : 2009
BACKGROUND: Bronchopulmonary dysplasia (BPD) is closely associated with ventilator-induced lung injury (VILI) in very preterm infants. The greatest risk of VILI may be in the immediate period after birth, when the lungs are surfactant deficient, still partially filled with liquid and not uniformly aerated. However, there have been very few studies that have examined this immediate post-birth period and identified the initial injury-related pathways that are activated. We aimed to determine if the early response genes; connective tissue growth factor (CTGF), cysteine rich-61 (CYR61) and early growth response 1 (EGR1), were rapidly induced by VILI in preterm lambs and whether ventilation with ..View full abstract
We thank Alison Thiel, Foula Sozo, Peter Dargaville and Naomi McCallion for technical assistance. This study was supported by the National Health and Medical Research Council of Australia.