Glial fibrillary acidic protein and S-100 colocalization in the enteroglial cells in dilated and nondilated portions of colon from chagasic patients
Alexandre BM da Silveira, Michelle AR Freitas, Enio C de Oliveira, Salustiano G Neto, Alejandro O Luquetti, John B Furness, Rodrigo Correa-Oliveira, Debora d'Avila Reis
HUMAN PATHOLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2009
After acute immunoreactive infestation with the Chagas' disease parasite, Trypanosoma cruzi, some patients develop chronic megacolon, whereas others remain asymptomatic. Chronic chagasic patients with gastrointestinal involvement exhibit inflammation and degeneration of enteric neurons. Our hypothesis is that enteric glial cells may be involved in the modulation of enteric inflammatory responses or even control the colon's dilatation. The aims of this study were to characterize the phenotype of enteric glial cells according to the expression of S-100 and glial fibrillary acidic protein and to look for correlation between these data and the neuronal loss in the colon of chagasic patients. We ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by funds from CNPq (Conselho Nacional de, Desenvolvimento Cientifico e Tecnologico) Ministerio da Ciencia e Tecnologia, Brazil, and the National Health and Medical Research Council of Australia (grant 400020).