Rabbit-specific fimbriae, Ral, alter the patterns of in vitro adherence and intestinal colonisation of rabbits by human-specific enteropathogenic E. coli

Abstract

Enteropathogenic Escherichia coli (EPEC) poses a significant threat to human health, causing diarrhoea in children worldwide, and is a leading cause of infant mortality in developing countries. The pathogenic effects of EPEC and other attaching-effacing (A/E) bacteria result from adhesion to the intestinal mucosa by a variety of mechanisms, including fimbrial adhesins, which are believed to contribute to the host and tissue specificity of EPEC by their interaction with specific receptors on cell surfaces. In this study we investigated the contribution of a fimbrial adhesin, Ral, of rabbit-specific EPEC (REPEC) to host specificity by introducing Ral into derivatives of human-specific EPEC (hE..