Cross-presentation of viral and self antigens by skin-derived CD103 dendritic cells

S Bedoui; PG Whitney; J Waithman; L Eidsmo; L Wakim; I Caminschi; RS Allan; M Wojtasiak; K Shortman; FR Carbone; AG Brooks; WR Heath

Journal article

Cross-presentation of viral and self antigens by skin-derived CD103 dendritic cells

S Bedoui, PG Whitney, J Waithman, L Eidsmo, L Wakim, I Caminschi, RS Allan, M Wojtasiak, K Shortman, FR Carbone, AG Brooks, WR Heath

Nature Immunology | NATURE PUBLISHING GROUP | Published : 2009

DOI: 10.1038/ni.1724

Abstract

Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a langerin-positive CD103+ dermal subset. We examined their involvement in the presentation of skin-associated viral and self antigens. Only the CD103+ subset efficiently presented antigens of herpes simplex virus type 1 to naive CD8+ T cells, although all subsets presented these antigens to CD4+ T cells. This showed that CD103+ DCs were the migratory subset most efficient at processing viral antigens into the major histocompatibility complex class I pathway, potentially through cross-presentation. This was supported by data showing only CD103+ DCs efficiently cross-presented skin-derived self antigens. Thi..

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University of Melbourne Researchers

Sammy Bedoui Author

Linda Wakim Author

Rhys Allan Author

Francis Carbone Author

Grants

Awarded by Howard Hughes Medical Institute

Funding Acknowledgements

We thank the flow cytometry facilities and animal facility staff of the Walter and Eliza Hall Institute of Medical Research and K. Field; we also thank B. Davies and J. Langley for technical assistance. Supported by Deutsche Forschungsgemeinschaft (BE 3285-1/2 to S. B.), the National Health and Medical Research Council of Australia (W. R. H., F. R. C., A. G. B. and P. G. W.) and the Howard Hughes Medical Institute (W. R. H.).