Journal article

The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells

Lisa M Ebert, Bee Shin Tan, Judy Browning, Suzanne Svobodova, Sarah E Russell, Naomi Kirkpatrick, Craig Gedye, Denis Moss, Sweet Ping Ng, Duncan MacGregor, Ian D Davis, Jonathan Cebon, Weisan Chen

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2008

Abstract

FoxP3 is a member of the forkhead family of transcription factors critically involved in the development and function of CD25(+) regulatory T cells (Treg). Until recently, FoxP3 expression was thought to be restricted to the T-cell lineage. However, using immunohistochemistry and flow cytometric analysis of human melanoma tissue, we detected FoxP3 expression not only in the tumor infiltrating Treg but also in the melanoma cells themselves. FoxP3 is also widely expressed by established human melanoma cell lines (as determined by flow cytometry, PCR, and Western blot), as well as cell lines derived from other solid tumors. Normal B cells do not express FoxP3; however, expression could be induc..

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University of Melbourne Researchers