Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.
Päivi Laiho, Tuija Hienonen, Auli Karhu, Lara Lipton, Yan Aalto, Huw JW Thomas, Karin Birkenkamp-Demtroder, Shirley Hodgson, Reijo Salovaara, Jukka-Pekka Mecklin, Heikki Järvinen, Sakari Knuutila, Sarah Halford, Torben F Ørntoft, Ian Tomlinson, Virpi Launonen, Richard Houlston, Lauri A Aaltonen
Oncogene | Published : 2003
We have allelotyped a series of 104 Finnish colorectal cancers (CRCs) using 372 polymorphic markers spaced, on average, at 10 cM intervals, and have made a comparison of the differences in the frequency of allelic imbalance (AI) between familial and sporadic cases. Differences in the frequency of allelic imbalance (loss of heterozygosity or amplification) at a number of loci were detected and these were evaluated through analysis of additional series of cancers using specific markers. The most consistent difference was observed at chromosome 20q13.1-13.3 characterized by a two fold difference between familial and nonfamilial disease in a total of 99 familial and 186 sporadic Finnish cases. T..View full abstract