IP-10-Mediated T Cell Homing Promotes Cerebral Inflammation over Splenic Immunity to Malaria Infection
Catherine Q Nie, Nicholas J Bernard, M Ursula Norman, Fiona H Amante, Rachel J Lundie, Brendan S Crabb, William R Heath, Christian R Engwerda, Michael J Hickey, Louis Schofield, Diana S Hansen
PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2009
Plasmodium falciparum malaria causes 660 million clinical cases with over 2 million deaths each year. Acquired host immunity limits the clinical impact of malaria infection and provides protection against parasite replication. Experimental evidence indicates that cell-mediated immune responses also result in detrimental inflammation and contribute to severe disease induction. In both humans and mice, the spleen is a crucial organ involved in blood stage malaria clearance, while organ-specific disease appears to be associated with sequestration of parasitized erythrocytes in vascular beds and subsequent recruitment of inflammatory leukocytes. Using a rodent model of cerebral malaria, we have ..View full abstract
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Awarded by NHMRC IRIISS
Supported by the NHMRC Project grant 356239, NHMRC Program Grant 215201, NHMRC IRIISS grant 361646 and Victorian State Government OIS grant. LS, BSC and WRH are International Research Scholars of the Howard Hughes Medical Institute.