Journal article
The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations
MP Johnson, LT Roten, TD Dyer, CE East, S Forsmo, J Blangero, SP Brennecke, R Austgulen, EK Moses
Human Genetics | SPRINGER | Published : 2009
Abstract
Preeclampsia is a heritable pregnancy disorder that presents new onset hypertension and proteinuria. We have previously reported genetic linkage to preeclampsia on chromosomes 2q, 5q and 13q in an Australian/New Zealand (Aust/NZ) familial cohort. This current study centered on identifying the susceptibility gene(s) at the 5q locus. We first prioritized candidate genes using a bioinformatic tool designed for this purpose. We then selected a panel of known SNPs within ten prioritized genes and genotyped them in an extended set of the Aust/NZ families and in a very large, independent Norwegian case/control cohort (1,139 cases, 2,269 controls). In the Aust/NZ cohort we identified evidence of a g..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
This work was supported by National Institutes of Health grants HD049847 (to E. K. M., S. P. B. and J. B.) and MH059490 (to J. B.); a grant from the Semp Russ Foundation of the San Antonio Area Foundation (to M. P. J.); The Norwegian University of Science and Technology (NTNU) (R. A.); the Central Norway Regional Health Authority; and the Medical Faculty and Office of International Relations at NTNU (to L. T. R., Ph. D. scholar). M. P. J. is the recipient of a Cowles Postdoctoral Fellowship. This investigation was conducted in facilities constructed with support from Research Facilities Improvement Program grants RR13556 and RR017515 from the National Center for Research Resources, National Institutes of Health. The Nord-Trondelag Health Study (the HUNT study) is a collaboration between the HUNT Research Centre, the Faculty of Medicine, NTNU, the Norwegian Institute of Public Health and the Nord-Trondelag County Council. We thank Dr. Jeremy Jowett for bioinformatic analyses and Mr. Anthony Borg for technical assistance. We thank all the preeclampsia families and unrelated preeclamptic women whose participation made this work possible and the support of all the clinicians and research midwives who contributed to this study.