Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
Emre Bora, Murat Yucel, Christos Pantelis
Journal of Affective Disorders | ELSEVIER SCIENCE BV | Published : 2009
BACKGROUND: Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD). METHODS: Following an extensive publication search on several databases, meta-analyses were conducted for 18 cognitive variables in studies that compared performances of euthymic BD patients (45 studies; 1423 subjects) or first-degree relatives of BD patients (17 studies; 443 subjects) with healthy controls. The effect of demographic variables and confounding factors like age of onset, duration of illness and medication status were analysed using the method of meta-regression. RESULTS: While response inhibition, set shifting, exe..View full abstract
Awarded by National Health & Medical Research Council (NH&MRC) Clinical Career Development Award
Murat Yucel was supported by a National Health & Medical Research Council (NH&MRC) Clinical Career Development Award (I.D. 509345).