Journal article
Prostatic Interstitial Cells in Ageing Guinea Pig Prostates
Snezana Kusljic, Anupa Dey, Dan-Thanh T Nguyen, Richard J Lang, Betty Exintaris
Current Urology | Ovid Technologies (Wolters Kluwer Health) | Published : 2008
DOI: 10.1159/000115375
Open access
Abstract
Objective: Prostatic interstitial cells (PIC) have been previously identified in the young guinea pig and human prostates and have been suggested to be a potential new therapeutic target for diseases of the prostate gland. In this study we have established the presence of PIC and their intercellular communication via connexin 43, in the ageing guinea pig prostate. Materials and Methods: Immunohistochemical and electrophysiological techniques were used. Results: Microscopic examination of preparations of guinea pig pros-tate revealed the presence of c-Kit immunoreactive cells in the region between the smooth muscle (SM) and glandular layers in ageing guinea pigs. Connexin 43 immunoreactive ce..
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