Serotonin depletion in the dorsal and ventral hippocampus: Effects on locomotor hyperactivity, prepulse inhibition and learning and memory
Wendy Adams, Snezana Kusljic, Maarten van den Buuse
NEUROPHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2008
We present an overview of our studies on the differential role of serotonergic projections from the median raphe nucleus (MRN) and dorsal raphe nucleus (DRN) in behavioural animal models with relevance to schizophrenia. Stereotaxic microinjection of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) into the MRN or one of its main projections regions, the dorsal hippocampus, induced a marked enhancement of phencyclidine-induced locomotor hyperactivity and a disruption of prepulse inhibition (PPI) in rats. There was no enhancement of locomotor hyperactivity induced by amphetamine or MK-801 or after 5,7-DHT lesions of the DRN or ventral hippocampus. Rats with dorsal hippocampus lesions..View full abstract
These studies were supported by a project grant from the National Health and Medical Research Council (NHMRC) of Australia. A van den Buuse is a NHMRC Senior Research Fellow and W. Adams is supported by an Australian Postgraduate Award. The authors are grateful to Olivia Dean for assistance with the ELISA results.