Tumor targeting by a multivalent single-chain Fv (scFv) anti-Lewis Y antibody construct
Marcus P Kelly, F-T Lee, Kiki Tahtis, Barbara E Power, Fiona E Smyth, Martin W Brechbiel, Peter J Hudson, Andrew M Scott
Cancer Biotherapy & Radiopharmaceuticals | MARY ANN LIEBERT, INC | Published : 2008
Awarded by NHMRC Program
The authors wish to thank Usha Krishnan for protein purification of the hu3S193 multimer and also Angela Rigopoulos, Dongmao Wang, and Sanja Coso for their assistance in the biodistribution study, Anthony Papenfuss for pharmacokinetic calculations, and the staff from the Department of Nuclear Medicine, Austin Hospital, for their assistance in the gamma-camera imaging of the animals. This research was funded by the NH&MRC Program Grant 290816 and, in part, by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. MPK was supported by a Melbourne Research Scholarship, University of Melbourne (Melbourne, Australia).