Journal article

Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females

EC Prom-Wormley, LJ Eaves, DL Foley, CO Gardner, KJ Archer, BK Wormley, HH Maes, BP Riley, JL Silberg

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2009

Abstract

BACKGROUND: Recent studies among males have reported a genotype-environment interaction (GxE) in which low-activity alleles at the monoamine oxidase A (MAOA) locus conferred greater sensitivity to the effects of childhood adversity on risk for conduct disorder (CD). So far, few studies of females have controlled for gene-environment correlation or used females heterozygous for this X-linked gene. METHOD: Logistic regression analysis of a sample of 721 females ages 8-17 years from the longitudinal Virginia Twin Study of Adolescent Behavioral Development (VTSABD) assessed the additive effects of MAOA genotypes on risk for CD, together with the main effect of childhood adversity and parental an..

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