Journal article
Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females
EC Prom-Wormley, LJ Eaves, DL Foley, CO Gardner, KJ Archer, BK Wormley, HH Maes, BP Riley, JL Silberg
PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2009
Abstract
BACKGROUND: Recent studies among males have reported a genotype-environment interaction (GxE) in which low-activity alleles at the monoamine oxidase A (MAOA) locus conferred greater sensitivity to the effects of childhood adversity on risk for conduct disorder (CD). So far, few studies of females have controlled for gene-environment correlation or used females heterozygous for this X-linked gene. METHOD: Logistic regression analysis of a sample of 721 females ages 8-17 years from the longitudinal Virginia Twin Study of Adolescent Behavioral Development (VTSABD) assessed the additive effects of MAOA genotypes on risk for CD, together with the main effect of childhood adversity and parental an..
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Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
Funding Acknowledgements
This work was supported by National Institutes of Health Grants MH-45268 and MH-068521 and NIMH Training Grant MH-20030. We acknowledge the contribution of the VTSABD, now part of the Mid-Atlantic Twin Registry (MATR), for ascertainment of subjects for this study. We thank Dr Dawn Thiselton for her helpful comments on earlier versions of this manuscript.