Journal article

An International Collaborative Family-Based Whole-Genome Linkage Scan for High-Grade Myopia

Yi-Ju Li, Jeremy A Guggenheim, Anuradha Bulusu, Ravikanth Metlapally, Diana Abbott, Francois Malecaze, Patrick Calvas, Thomas Rosenberg, Sandrine Paget, Rosalind C Creer, George Kirov, Michael J Owen, Bei Zhao, Tristan White, David A Mackey, Terri L Young

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2009

Abstract

PURPOSE: Several nonsyndromic high-grade myopia loci have been mapped primarily by microsatellite markers and a limited number of pedigrees. In this study, whole-genome linkage scans were performed for high-grade myopia, using single nucleotide polymorphisms (SNPs) in 254 families from five independent sites. METHODS: Genomic DNA samples from 1411 subjects were genotyped (Linkage Panel IVb; Illumina, San Diego, CA). Linkage analyses were performed on 1201 samples from 10 Asian, 12 African-American, and 221 Caucasian families, screening for 5744 SNPs after quality-control exclusions. Two disease states defined by sphere (SPH) and spherical equivalence (SE; sphere+cylinder/2) were analyzed. Pa..

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Grants

Awarded by National Institutes of Health (NIH)


Awarded by College of Optometrists


Awarded by Sir Jules Thorn Trust


Awarded by NATIONAL EYE INSTITUTE


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Funding Acknowledgements

Supported by National Institutes of Health (NIH) Grant R01 EY014685 (TLY); NIH CIDR Grant N01-HG-65403 (TLY); a Research to Prevent Blindness, Inc. Lew R. Wasserman Award (TLY); College of Optometrists Grant NdB/TM/Gug/4/6/1 (JAG); and Sir Jules Thorn Trust Grant RSC047 (JAG).