Journal article

Anterior cingulate volume in adolescents with first-presentation borderline personality disorder

Sarah Whittle, Andrew M Chanen, Alex Fornito, Patrick D McGorry, Christos Pantelis, Murat Yuecel



Reports of volumetric abnormalities in the anterior cingulate cortex (ACC) in adults with established borderline personality disorder (BPD) are inconsistent, and it is not known whether such abnormalities are present early in the disorder. We aimed to investigate ACC volume in a first-presentation teenage BPD sample with minimal exposure to treatment. Fifteen female BPD patients and 15 healthy female control participants underwent magnetic resonance imaging (MRI) scanning. ACC volumes were estimated using a reliable method that accounts for inter-individual variation in sulcal morphology, and measurements were compared between the two groups. Analysis of variance revealed a decrease in volum..

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Awarded by Victorian Health Promotion Foundation, Melbourne, Australia

Awarded by National Health and Medical Research Council (NHMRC), Canberra, Australia

Awarded by NHMRC Clinical Career Development

Awarded by NHMRC

Funding Acknowledgements

The authors thank the patients and staff of the HYPE Clinic at ORYGEN Youth Health. Thanks are also due to Ms. Caroline Weinstein, Dr. Dennis Velakoulis, A/Prof. Warrick Brewer and Ms. Deidre Smith for assistance with data collection.Funding/Support: This work was supported in part by grants 98-0198 from the Victorian Health Promotion Foundation, Melbourne, Australia and grant 990748 from the National Health and Medical Research Council (NHMRC), Canberra, Australia. ORYGEN Research Centre is supported by an unrestricted grant from the Colonial Foundation, Melbourne, Australia. Neuroimaging analysis was facilitated by the Melbourne Neuropsychiatry Centre's Imaging Laboratory. managed by Ms Bridget Soulsby and supported by Neurosciences Victoria. Dr Sarah Whittle is supported by an Australian Research Council Postdoctoral Fellowship. Dr Murat Yucel is supported by an NHMRC Clinical Career Development Grant 509345, as well as an NHMRC Program Grant 350241.