Journal article
ECSA/DPPA2 is an embryo-cancer antigen that Is coexpressed with cancer-testis antigens in non-small cell lung cancer
T John, OL Caballero, SJ Svobodová, A Kong, R Chua, J Browning, S Fortunato, S Deb, M Hsu, CA Gedye, ID Davis, N Altorki, AJ Simpson, YT Chen, M Monk, JS Cebon
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2008
Abstract
Purpose: Cancer cells recapitulate many behaviors of pluripotent embryonic cells such as unlimited proliferation, and the capacity to self-renew and to migrate. Embryo-cancer sequence A (ECSA), later named developmental pluripotency associated-2 (DPPA2), is an embryonic gene initially isolated from pluripotent human preimplantation embryos. We hypothesized that ECSA/ DPPA2 would be quiescent in most normal tissues but expressed in cancers and may therefore be a useful target for immunotherapy. Experimental Design: ECSA/DPPA2 expression was examined in a panel of normal and tumor tissue by reverse transcription PCR, quantitative real-time PCR, and immunohistochemistry. A panel of 110 non - sm..
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