Journal article
The retinoic acid receptor alpha (RARA) gene is not associated with myopia, hypermetropia, and ocular biometric measures
S Veerappan, M Schäche, KK Pertile, FMA Islam, CY Chen, P Mitchell, M Dirani, PN Baird
Molecular Vision | MOLECULAR VISION | Published : 2009
Abstract
Purpose: The Retinoic Acid Receptor Alpha (RARA) gene is a potential candidate gene for myopia due to its differential expression in animal models during experimentally induced myopia. To test for whether RARA is associated with myopia we have undertaken a case-control study assessing for associations between RARA and myopia, hypermetropia, and ocular biometric measures. Methods: A total of 802 Anglo-Celtic individuals were genotyped. Five tag single nucleotide polymorphisms (tSNPs) in RARA with an r2 of 0.8 and a minor allele frequency greater than 5% were selected for genotyping. Genotype frequencies of these 5 tSNPs were compared between individuals with emmetropia and those with myopia o..
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Funding Acknowledgements
The authors would like to thank the volunteers of the GEM, VIP, and BMES studies for their participation. This research was supported by the Australian Federal Government through the Cooperative Research Centres Program, the National Health and Medical Research Council of Australia, Joan and Peter Clemenger Trust, Helen Macpherson Smith Trust, L. E. W Carty Trust, Angior Family Foundation, The Myra Stoicesco Charitable Trust as administered by Equity Trustees Ltd and the Sunshine Foundation.