Journal article
The predictive performance of plasma neutrophil gelatinase-associated lipocalin (NGAL) increases with grade of acute kidney injury
A Haase-Fielitz, R Bellomo, P Devarajan, M Bennett, D Story, G Matalanis, U Frei, D Dragun, M Haase
Nephrology Dialysis Transplantation | Published : 2009
DOI: 10.1093/ndt/gfp234
Abstract
Background. In adult cardiac surgery, the predictive value for AKI of neutrophil gelatinase-associated lipocalin (NGAL) appears to have wide variability. The choice of definition of acute kidney injury (AKI) might, at least in part, account for such variability.Methods. In a prospective study of 100 adult cardiac surgery patients, we assessed the value of postoperative plasma NGAL in predicting AKI according to the degree of severity used for its definition.Results. The predictive value of plasma NGAL varied according to the AKI definition used and was higher for more severe AKI (increase in creatinine >50: mean AUC-ROC 0.79 ± 0.01) compared to less severe AKI (>25: mean AUC-ROC 0.65 ± 0.02)..
View full abstractGrants
Funding Acknowledgements
Dr Haase holds a postdoctoral Fcodor-Lynen research fellowship from the Alexander von Humboldt-Foundation, Germany. This study was partly funded by a grant from the Australian and New Zealand College of Anaesthetists and by the Austin Hospital Anesthesia and Intensive Care Trust Fund. R.B. and M.H. conceived the study. M.H., A.H.F., P.D. and R.B. participated in the design of the study, performed the statistical analysis and drafted the manuscript. D.S., D.D., M.B., G.M. and U.F. participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.