Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042

RL Milne; J Benítez; H Nevanlinna; T Heikkinen; K Aittomäki; C Blomqvist; JI Arias; MP Zamora; B Burwinkel; CR Bartram; A Meindl; RK Schmutzler; A Cox; I Brock; G Elliott; MWR Reed; MC Southey; L Smith; AB Spurdle; JL Hopper; FJ Couch; JE Olson; X Wang; Z Fredericksen; P Schürmann; M Bremer; P Hillemanns; T Dörk; P Devilee; CJ Van Asperen; RAEM Tollenaar; C Seynaeve; P Hall; K Czene; J Liu; Y Li; S Ahmed; AM Dunning; M Maranian; PDP Pharoah; G Chenevix-Trench; J Beesley; NV Bogdanova; NN Antonenkova; IV Zalutsky; H Anton-Culver; A Ziogas; H Brauch; C Justenhoven; YD Ko; S Haas; PA Fasching; R Strick; AB Ekici; MW Beckmann; GG Giles; G Severi; L Baglietto; DR English; O Fletcher; N Johnson; I Dos Santos Silva; J Peto; C Turnbull; S Hines; A Renwick; N Rahman; BG Nordestgaard; SE Bojesen; H Flyger; D Kang; KY Yoo; DY Noh; A Mannermaa; V Kataja; VM Kosma; M García-Closas; S Chanock; J Lissowska; LA Brinton; J Chang-Claude; S Wang-Gohrke; CY Shen; HC Wang; JC Yu; ST Chen; M Bermisheva; T Nikolaeva; E Khusnutdinova; MK Humphreys; J Morrison; R Platte; DF Easton

Journal article

Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042

RL Milne, J Benítez, H Nevanlinna, T Heikkinen, K Aittomäki, C Blomqvist, JI Arias, MP Zamora, B Burwinkel, CR Bartram, A Meindl, RK Schmutzler, A Cox, I Brock, G Elliott, MWR Reed, MC Southey, L Smith, AB Spurdle, JL Hopper Show all

Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2009

DOI: 10.1093/jnci/djp167

Abstract

BackgroundA recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)-positive breast cancer. We attempted to confirm this association using the Breast Cancer Association Consortium.Methods2q35-rs13387042 SNP was genotyped for 31 510 women with invasive breast cancer, 1101 women with ductal carcinoma in situ, and 35 969 female control subjects from 25 studies. Odds ratios (ORs) were estimated by logistic regression, adjusted for study. Heterogeneity in odds ratios by each of age, ethnicity, and study was assessed by fitting interaction terms. Heterogeneity by each of invasiveness, family histor..

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