Intrahepatic cholestasis of pregnancy: When should you look further?
Winita Hardikar, Shivani Kansal, Ronald PJ Oude Elferink, Peter Angus
WORLD JOURNAL OF GASTROENTEROLOGY | W J G PRESS | Published : 2009
Pruritus with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy (ICP), a condition associated with significant fetal complications. Although the etiology of ICP is unclear in many cases, certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver disease. We report a kindred of Anglo-Celtic descent, among whom many members present with ICP, gallstones or cholestasis related to use of oral contraception. Genetic studies revealed a novel mutation in the ABCB4 gene, whic..View full abstract