Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss

L Yip; S Zaloumis; D Irwin; G Severi; J Hopper; G Giles; S Harrap; R Sinclair; J Ellis

Journal article

Gene-wide association study between the aromatase gene (CYP19A1) and female pattern hair loss

L Yip, S Zaloumis, D Irwin, G Severi, J Hopper, G Giles, S Harrap, R Sinclair, J Ellis

British Journal of Dermatology | WILEY | Published : 2009

DOI: 10.1111/j.1365-2133.2009.09186.x

Abstract

Background Female pattern hair loss (FPHL) is a common trait in which androgens and oestrogens may have a pathogenic role. The aromatase enzyme converts androgens to oestrogens in scalp hair follicles and is differentially expressed in balding and nonbalding scalps of women. Sequence variation in the gene encoding aromatase, CYP19A1, might influence the risk of developing FPHL. Objectives To examine the role of CYP19A1 genetic variation in the heritability of FPHL. Methods We investigated associations between FPHL and 61 tag single nucleotide polymorphisms (SNPs) representing variation in and around CYP19A1 in 484 caucasian women with grades 3-5 FPHL on the Sinclair scale, and 471 caucasian ..

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University of Melbourne Researchers

Sophie Zaloumis Author

Graham Giles Author

Stephen Harrap Author

Rodney Sinclair Author

Related Projects (3)

Epidemiology of chronic disease, health interventions and DNA studies

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Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

We wish to acknowledge Ms Angela Lamantia and Dr Shannon Harrison for their assistance with DNA extractions, Dr David Muller for his assistance with selection of subjects from the Melbourne Collaborative Cohort Study (MCCS), the medical photography centre at The Skin and Cancer Foundation of Victoria, and Dr Katrina Scurrah for her advice on statistical analysis. We also thank all the participants who took part in this study. We gratefully acknowledge Epiderm (formerly the Australasian Dermatology Research and Education Foundation) for funding of this study. The MCCS is supported by the Australian National Health and Medical Research Council (grants 209057, 251533, 396414, 504711). Cohort recruitment and follow-up is funded by The Cancer Council Victoria.