Experience on the barnes spatial maze influences pkcγ levels in the hippocampus

Abstract

In order to examine hippocampal plasticity following spatial learning, expression of the γ isoform of protein kinase C (PKCγ) was analyzed in mice, following experience and training on the Barnes spatial maze. Both context-exposed (animals familiarized with the maze but not trained) and trained animals (animals trained to escape the maze using spatial cues) showed increased immunoreactivity to PKCγ in the CA1 region in comparison to naive, home-caged animals. However, there were no quantitative differences in PKCγ immunoreactivity between context-exposed and trained animals. These changes suggest that spatial experience and training result in altered activation of PKCγ, consistent with the i..