Journal article
Myc - What we have learned from flies
NA Siddall, JI Lin, GR Hime, LM Quinn
Current Drug Targets | Published : 2009
Abstract
The Myc family proteins are key regulators of animal growth and development. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Extensive studies have revealed much about both upstream regulators and downstream target genes in the sphere of Myc regulation. Here, we review some of the critical discoveries made using the Drosophila model, in particular those studies that have explored the essential role of the Myc family in growth and cell cycle progression and identified many of the upstream signals and downstream targets common to both c-Myc and dMyc. © 2009 Bentham Science Publishers Ltd.
Grants
Funding Acknowledgements
We thank Ben Britten Smith for graphic design. Thanks to Bob Eisenman and David Stein for the dMyc antibodies and to the Vienna Drosophila Research Centre (VDRC) for the dMyc RNAi lines. This work was supported by grants from the Cancer Council of Victoria (CCV) and the Australian Research Council Centre of Excellence in Biotechnology and Development (ARCOECBD). LQ is a National Health and Medical Research Council (NHMRC) RD Wright Research Fellow and Jane Lin holds an Australian Postgraduate Award.