Journal article
Inhibition of the bradycardic component of the von Bezold-Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: Involvement of medullary receptors
F Netzer, N Mandjee, AJ Verberne, JF Bernard, M Hamon, R Laguzzi, C Sévoz-Couche
European Journal of Neuroscience | WILEY | Published : 2009
Abstract
Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold-Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold-Jarisch and the carotid chemoreceptor reflexes. In addition, as 5-HT 3, NK 1 and GABA A rece..
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Funding Acknowledgements
We are deeply grateful to Dr Julian Paton for his expert remarks and suggestions concerning this study. This research was supported by grants from INSERM and Universite Pierre et Marie Curie. F.N. was supported by a fellowship from the Chancellerie des Universites during the performance of this work. We are grateful to Glaxo-Smith-Kline (Harlow, UK) for the generous gift of GR205171.