Deoxyamphimedine, a Pyridoacridine Alkaloid, Damages DNA via the Production of Reactive Oxygen Species
Kathryn M Marshall, Cynthia D Andjelic, Deniz Tasdemir, Gisela P Concepcion, Chris M Ireland, Louis R Barrows
MARINE DRUGS | MDPI | Published : 2009
Marine pyridoacridines are a class of aromatic chemicals that share an 11H-pyrido[4,3,2-mn]acridine skeleton. Pyridoacridine alkaloids display diverse biological activities including cytotoxicity, fungicidal and bactericidal properties, production of reactive oxygen species (ROS) and topoisomerase inhibition. These activities are often dependent on slight modifications to the pyridoacridine skeleton. Here we demonstrate that while structurally similar to neoamphimedine and amphimedine, the biological activity of deoxyamphimedine differs greatly. Deoxyamphimedine damages DNA in vitro independent of topoisomerase enzymes through the generation of reactive oxygen species. Its activity was decre..View full abstract
Awarded by ICBG
Awarded by FOGARTY INTERNATIONAL CENTER
Awarded by NATIONAL CANCER INSTITUTE
The authors would like to thank Dr. Joseph A. Holden ( Department of Pathology, University of Utah) for support and helpful discussions. Research supported by ICBG grant UO1 TW006671 and RO1 CA 36622.