Journal article

Nonalbuminuric Renal Impairment in Type 2 Diabetic Patients and in the General Population (National Evaluation of the Frequency of Renal Impairment cO-existing with NIDDM [NEFRON] 11)

Merlin C Thomas, Richard J MacIsaac, George Jerums, Andrew Weekes, John Moran, Jonathan E Shaw, Robert C Atkins



OBJECTIVE Most diabetic patients with impaired renal function have a urinary albumin excretion rate in the normal range. In these patients, the etiology of renal impairment is unclear, and it is also unclear whether this nonalbumunuric renal impairment is unique to diabetes. RESEARCH DESIGN AND METHODS In this study, we examined the frequency and predictors of nonalbumunuric renal impairment (estimated glomerular filtration rate [eGFR] <60 ml/min per 1.73 m(2)) in a nationally representative cohort of 3,893 patients with type 2 diabetes and compared our findings with rates observed in the general population from the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) survey (n = 11,24..

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Funding Acknowledgements

The NEFRON study was conducted as a collaboration between the Baker Heart Research Institute, Kidney Health Australia, and Servier Australia. It was unconditionally funded by Servier Australia. The AusDiab study was supported by the Commonwealth Department of Health and Aged Care; State Governments of Queensland, South Australia, Tasmania, Western Australia, and Victoria and Territory Health Services; the Australian Kidney Foundation; Diabetes Australia (Northern Territory); and the International Diabetes Institute. M.C.T. is supported by the Bootle Award from Kidney Health Australia and funding from the National Health and Medical Research Council and the Juvenile Diabetes Research Foundation.The AusDiab study was also supported by Eli Lilly (Australia); Janssen-Cilag (Australia); Abbott (formally Knoll) (Australia); Merck Lipha s.a. Alphapharm; Merck Sharp & Dohme (Australia); Pharmacia and Upjohn; Roche Diagnostics; GlaxoSmithKline; Bio-Rad Laboratories; HITECH Pathology; and Qantas Airways. No other potential conflicts of interest relevant to this article were reported.