Journal article
11C-PiB PET studies in typical sporadic Creutzfeldt - Jakob disease
VL Villemagne, CA McLean, K Reardon, A Boyd, V Lewis, G Klug, G Jones, D Baxendale, CL Masters, CC Rowe, SJ Collins
Journal of Neurology Neurosurgery and Psychiatry | Published : 2009
Abstract
Objective: Brain amyloid imaging using positron emission tomography (PET) is of increasing importance in the premortem evaluation of dementias, particularly in relation to Alzheimer disease (AD). The purpose of this study was to explore the premortem diagnostic utility of 11C-PiB PET in sporadic Creutzfeldt-Jakob disease (CJD). Methods: Two patients, 72 and 59 years old, underwent evaluation for rapidly progressive cognitive decline, dying after illness durations of 5 and 7 months, respectively. As part of their comprehensive assessment, 18F-FDG PET and 11C-PiB PET studies were performed approximately 2-4 weeks prior to death, and the brain regional distributions compared with those from coh..
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Funding Acknowledgements
PET studies were supported in part by funds from the Austin Hospital Medical Research Foundation, Neurosciences Victoria and the University of Melbourne. The Australian National Creutzfeldt-Jakob disease Registry is funded by the Commonwealth Department of Health and Ageing.