Journal article
The relationship between nicotinic receptors and cognitive functioning in healthy aging: An in vivo positron emission tomography (PET) study with 2-[ 18F]Fluoro-A-85380
JR Ellis, PJ Nathan, VL Villemagne, RS Mulligan, KA Ellis, HJ Tochon-Danguy, JG Chan, GJ O'Keefe, J Bradley, G Savage, CC Rowe
Synapse | WILEY | Published : 2009
DOI: 10.1002/syn.20642
Abstract
Extensive experimental and neuropathological evidence supports the general hypothesis that decline in the basal forebrain cholinergic system contributes significantly to age-related cognitive impairment. Postmortem studies suggest reductions in neuronal nicotinic acetylcholine receptors (nAChRs, particularly the α4β2 subtype) with aging. This study aimed to determine the distribution of α4β2-subtype nAChRs in vivo by 2-FA PET in healthy subjects (aged 21-83) and to establish whether there is an age-related decline in nAChRs. Furthermore, the relationship between PET measures of 2-FA binding and neurobehavioral measures of cognitive function was investigated. All participants were nonsmokers ..
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Funding Acknowledgements
Austin Hospital Medical Research Fund, Australian Rotary Health Fund, the Monash University Postgraduate Publication Award scheme, National Health and Medical Research Council (NHMRC) of Australia, the Alzheimers Australia Research Foundation (AARF).