Journal article

Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study

C Sun, JJ Wang, FM Islam, SR Heckbert, R Klein, DS Siscovick, BEK Klein, TY Wong

Journal of Human Hypertension | NATURE PUBLISHING GROUP | Published : 2009

Abstract

We examined the associations of single nucleotide polymorphisms (SNPs) in three candidate hypertension genes, alpha-adducin (ADD1/G460W), beta2-adrenergic receptor (ADRB2/Arg16Gly and Gln27Glu) and G-protein beta3 subunit (GNB3/C825T), with retinal arteriolar calibre (an intermediate marker of chronic hypertension) and venular calibre. Data in 1842 participants (1554 whites and 288 African Americans) aged 69-96 years from the Cardiovascular Health Study with genotype and retinal vascular calibre data were included. A computer-assisted method was used to measure retinal vascular calibre. We analysed four SNPs and multilocus interaction for three genes. All SNPs were in Hardy-Weinberg equilibr..

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Grants

Awarded by National Heart, Lung, and Blood Institute


Awarded by National Institute on Aging


Awarded by NHLBI


Awarded by DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

The research reported in this paper was supported by contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133 and U01 HL080295 from the National Heart, Lung, and Blood Institute, and grant AG015366 from National Institute on Aging, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by grant R21-HL077166 from NHLBI, NIH and the Sylvia and Charles Viertel Clinical Investigator Award (TYW). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm.