Heritability of central corneal thickness in nuclear families

Abstract

PURPOSE. Many ocular parameters show strong heritable tendencies. The significance of central corneal thickness (CCT) in the context of glaucoma has been the subject of much debate recently, but its heritability has not been extensively explored. This study was designed to investigate the parent- child heritability of CCT among groups who have CCT considered to be at the extreme ends of the normal range. METHODS. Index cases were recruited through a tertiary referral center if their CCT was greater than 578 μm (thick) or less than 510 μm (thin), representing ± 1 SD from a previously published meta-analys is mean of 544 μm (34 μm SD). Subsequently, CCT was measured in all available family mem..