Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories
Stephen J Wood, Christos Pantelis, Alison R Yung, Dennis Velakoulis, Patrick D McGorry
MEDICAL JOURNAL OF AUSTRALIA | AUSTRALASIAN MED PUBL CO LTD | Published : 2009
Neuroimaging studies of individuals at risk of psychosis have the potential to identify markers predictive of illness onset and features that progress with transition. To date, reduced brain volumes have shown weak predictive value for onset of psychotic illness. All published longitudinal studies of the transition to psychosis show progressive brain changes that are not seen in at-risk individuals who do not develop the disorder. Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia.
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Awarded by National Health and Medical Research Council (NHMRC)
Research described in this article was supported by the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Program Grant 350241 and Project Grants 299966, 252777, 236175, 209062, 11231, 991664, 145627, 145737, 981112, 970598, 970391), the Stanley Foundation, and the Ian Potter Foundation. Stephen Wood has received an NHMRC Clinical Career Development Award and a NARSAD Young Investigator Award; Patrick McGorry's work on HPA axis function was supported by a NARSAD Distinguished Investigator Award; and Christos Pantelis was awarded the Selwyn-Smith Medical Research Prize from the University of Melbourne for work described in this article.