Effects of Salt Supplementation on the Albuminuric Response to Telmisartan With or Without Hydrochlorothiazide Therapy in Hypertensive Patients With Type 2 Diabetes Are Modulated by Habitual Dietary Salt Intake
Elif I Ekinci, Georgina Thomas, David Thomas, Cameron Johnson, Richard J MacIsaac, Christine A Houlihan, Sue Finch, Sianna Panagiotopoulos, Chris O'Callaghan, George Jerums
DIABETES CARE | AMER DIABETES ASSOC | Published : 2009
OBJECTIVE This prospective randomized double-blind placebo-controlled crossover study examined the effects of sodium chloride (NaCl) supplementation on the antialbuminuric action of telmisartan with or without hydrochlorothiazide (HCT) in hypertensive patients with type 2 diabetes, increased albumin excretion rate (AER), and habitual low dietary salt intake (LDS; 200 mmol sodium/24 h on two of three consecutive occasions). RESEARCH DESIGN AND METHODS Following a washout period, subjects (n = 32) received 40 mg/day telmisartan for 4 weeks followed by 40 mg telmisartan plus 12.5 mg/day HCT for 4 weeks. For the last 2 weeks of each treatment period, patients received either 100 mmol/day NaCl or..View full abstract
During the period of this work, E.I.E. was supported by grants from the Austin Hospital Medical Research Foundation and the National Health and Medical Research Council.This work was supported by a Pfizer CVL grant and an unconditional educational grant from Boehringer Ingelheim. No other potential conflicts of interest relevant to this article were reported.We thank Aysel Akdeniz, Judy Winikoff, and Melinda Millard and the staff of the deparunent. of nuclear medicine, clinical pharmacology, and pharmacy for their assistance. In addition, we would like to thank all the patients who participated in this demanding study.