Journal article
Acute effects of hyperoxia on resting pattern of ventilation and dyspnoea in COPD
R Moore, D Berlowitz, J Pretto, D Brazzale, L Denehy, B Jackson, C McDonald
Respirology | WILEY | Published : 2009
Abstract
Background and objective: Hyperoxia has been shown to reduce resting ventilation, hyperinflation and dyspnoea in patients with severely hypoxaemic COPD. This study assessed the effects of hyperoxia on these resting measures in patients with COPD of varying disease severity and characterized those patients who responded. Methods: Measurements of dyspnoea (Borg score), oxyhaemoglobin saturation (SpO2), inspiratory capacity (IC), minute ventilation, tidal volume, breathing and cardiac frequency were performed at rest in 51 patients with COPD while they breathed air and 44% oxygen, in a randomized double-blinded fashion. Results: Hyperoxia induced significant reductions in cardiac frequency and ..
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Funding Acknowledgements
The authors wish to acknowledge the technical assistance of Chrissie Risteski, Nadia Gagliardi (Northern Clinical Research Centre, The Northern Hospital) and Faiyaz Tambuwala (Department of Respiratory and Sleep Medicine, Austin Hospital). This project has been supported by The National Health and Medical Research Council (Australia); The Northern Clinical Research Centre, Epping, Victoria, Australia; The Victorian Tuberculosis and Lung Association, Australia; The Austin Hospital Medical Research Foundation, Victoria, Australia; Air Liquide Limited; Boehringer Ingelheim Pty Limited.