Journal article

Sexual side-effects of contemporary antidepressants: review

Isaac Schweitzer, Kay Maguire, Chee Ng

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2009

Abstract

The aim of the present study was to review the sexual side-effects of contemporary antidepressants in Australia, comparing the selective serotonin re-uptake inhibitors (SSRIs) with venlafaxine, reboxetine, mirtazepine, duloxetine, bupropion, desvenlafaxine and agomelatine. Double-blind, randomized comparative studies of these antidepressants that included assessment of sexual dysfunction with validated rating scales in patients with major depressive disorder were identified from the literature using MEDLINE, EMBASE and PsychINFO databases. Bupropion and duloxetine caused significantly less sexual dysfunction than the SSRIs in short-term studies and reboxetine significantly less in both short..

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University of Melbourne Researchers

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Funding Acknowledgements

Professor Schweitzer and Associate Professor Ng have served on pharmaceutical industry advisory boards over the past 3 years (Wyeth and Eli Lilly Advisory Boards). Associate Professor Chee has received research grant support from Wyeth and Lundbeck. Both have received honoraria for lectures and travel grants from pharmaceutical companies. This paper was supported by an unrestricted educational grant from Servier Laboratories.