Effect of topical alkane vapocoolant spray on pain with intravenous cannulation in patients in emergency departments: randomised double blind placebo controlled trial
Ramzi Hijazi, David Taylor, Joanna Richardson
BMJ-BRITISH MEDICAL JOURNAL | BMJ PUBLISHING GROUP | Published : 2009
OBJECTIVE: To assess the efficacy, acceptability, and safety of a topical alkane vapocoolant in reducing pain during intravenous cannulation in adults. DESIGN: Randomised double blind placebo controlled trial. SETTING: Emergency department of a metropolitan teaching hospital. PARTICIPANTS: 201 adult patients (54% male), mean (SD) age 58.2 (19.5) years, who required intravenous cannulation. INTERVENTIONS: Less than 15 seconds before cannulation, the skin area was sprayed with either water (control, n=98) or vapocoolant (intervention, n=103), from a distance of 12 cm for 2 seconds. The intervention spray was a blend of propane, butane, and pentane. MAIN OUTCOME MEASURES: Pain with cannulation ..View full abstract
This study was funded by an advanced medical science grant from the University of Melbourne, Victoria, Australia. There were no study sponsors. The authors were entirely independent from the funders. The funders had no role in the project.