Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer
Jenny Chia, Kim Pin Yeo, James C Whisstock, Michelle A Dunstone, Joseph A Trapani, Ilia Voskoboinik
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2009
We thank J. Cebon, D. Bowtell, J. Sambrook, M. Smyth, G. McArthur, and J. Zalcberg for helpful comments on the manuscript. This work was supported by a Senior Principal Research Fellowship and Program Grant (to J. A. T.), a R. D. Wright Fellowship and Project Grant (to I. V.), a Doherty Fellowship (to M. D.)(all from the National Health and Medical Research Council of Australia), and an Australian Research Council Federation Fellowship (to J. C. W.).