Journal article
Retinal microvascular abnormalities and cognitive decline The ARIC 14-year follow-up study
SR Lesage, TH Mosley, TY Wong, M Szklo, D Knopman, DJ Catellier, SR Cole, R Klein, J Coresh, LH Coker, AR Sharrett
NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
Abstract
BACKGROUND: Because retinal and cerebral arterioles share similar pathologic processes, retinal microvascular changes are expected to be markers of cerebral small vessel disease (SVD). To better understand the role of SVD in cognitive function, we investigated the relationship between retinal microvascular abnormalities and longitudinal changes in cognitive function in a community-based study. METHODS: A total of 803 participants underwent 4 cognitive assessments between 1990-1992 and 2004-2006, using the Word Fluency (WF) test, Digit Symbol Substitution (DSS), and Delayed Word Recall as well as retinal photography in 1993-1995. Covariate adjusted random effects linear models for repeated me..
View full abstractRelated Projects (1)
Grants
Awarded by NCRR NIH HHS
Awarded by NEI NIH HHS
Awarded by NHLBI NIH HHS
Awarded by NIA NIH HHS
Awarded by NIDDK NIH HHS
Awarded by PHS HHS
Awarded by WHI NIH HHS
Awarded by DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES
Awarded by NATIONAL EYE INSTITUTE
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Awarded by NATIONAL INSTITUTE ON AGING