Journal article

Retinal microvascular abnormalities and cognitive decline The ARIC 14-year follow-up study

SR Lesage, TH Mosley, TY Wong, M Szklo, D Knopman, DJ Catellier, SR Cole, R Klein, J Coresh, LH Coker, AR Sharrett

NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009

Abstract

BACKGROUND: Because retinal and cerebral arterioles share similar pathologic processes, retinal microvascular changes are expected to be markers of cerebral small vessel disease (SVD). To better understand the role of SVD in cognitive function, we investigated the relationship between retinal microvascular abnormalities and longitudinal changes in cognitive function in a community-based study. METHODS: A total of 803 participants underwent 4 cognitive assessments between 1990-1992 and 2004-2006, using the Word Fluency (WF) test, Digit Symbol Substitution (DSS), and Delayed Word Recall as well as retinal photography in 1993-1995. Covariate adjusted random effects linear models for repeated me..

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