Journal article
Quantitative genetic analysis of the retinal vascular caliber: The australian twins eye study
C Sun, G Zhu, TY Wong, AW Hewitt, JB Ruddle, L Hodgson, GW Montgomery, TL Young, CJ Hammond, JE Craig, NG Martin, M He, DA MacKey
Hypertension | Published : 2009
Abstract
Research into the genetic effects and specific genes associated with retinal vascular caliber, a risk marker of cardiovascular diseases, may provide new insights into the genetic contribution of early microvascular disease. A combined 374 monozygotic and 536 dizygotic twin pairs and 322 siblings from the Twins Eye Study in Tasmania and the Brisbane Adolescent Twin Study underwent complete ophthalmic examinations, including retinal photography, and bilateral retinal vascular caliber was measured. Structural equation modeling was used to estimate the heritability. Genome-wide linkage analysis was conducted on 836 individuals from 381 Brisbane Adolescent Twin Study families, with adjustments fo..
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Awarded by National Eye Institute
Funding Acknowledgements
The genome scans were supported by the Australian National Health and Medical Research Council Program in Medical Genomics (NHMRC-219178 to N. G. M. and G. W. M.) and the Center for Inherited Disease Research at Johns Hopkins University (to N. G. M.). The Center for Inherited Disease Research is fully funded through a federal contract from the National Institutes of Health to the Johns Hopkins University (contract No. N01-HG-65403). The research reported in this article was supported by Ophthalmic Research Institute of Australia (to D. A. M., C. S., and J. B. R.), the Foundation for Children Australia (to T. Y. W., D. A. M., and C. S.), the National Health and Medical Research Council, Canberra Australia (project grant 350415 to D. A. M.), the Clifford Craig Medical Research Trust, National Institutes of Health, National Eye Institute (RO1 EY018246-01, to T. L. Y., D. A. M., C. J. H., and N. G. M.). C. S. is the recipient of a National Health and Medical Research Council Public Health Postgraduate Scholarship. D. A. M. is the recipient of the Pfizer Australia Senior Research Fellowship.