Journal article
Low-fouling poly(N-vinyl pyrrolidone) capsules with engineered degradable properties
CR Kinnane, GK Such, G Antequera-García, Y Yan, SJ Dodds, LM Liz-Marzan, F Caruso
Biomacromolecules | AMER CHEMICAL SOC | Published : 2009
DOI: 10.1021/bm900673m
Abstract
We report the assembly of low-fouling polymer capsules with engineered deconstruction properties by using a combination of layer-by-layer (LbL) assembly and click chemistry. Preformed, hydrogen-bonded multilayers of alkyne-functionalized poly(N-vinyl pyrrolidone) (PVPONAlk) and poly(methacrylic acid) (PMA) assembled at pH 4 on silica particles were cross-linked with a bisazide linker (containing a disulfide link) through alkyne-azide click chemistry. Following dissolution of the silica template particles, and altering the solution pH to 7.2 to disrupt hydrogen bonding between PVPONAlk and PMA to effect removal of PMA, stable, cross-linked PVPON capsules were obtained. The presence of the dis..
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Funding Acknowledgements
This work was supported by the Australian Research Council under the Federation Fellowship (F.C.) and Discovery Project schemes (F.C. and G.K.S.). G.A.-G. and L.M.L.-M. acknowledge financial support from Rede Galega de Nanomedicina (Xunta de Galicia, Spain) and Consolider-Ingenio Nanobiomed (Spanish MEC, Spain).