Blood pressure lowering and outcomes in type 2 diabetes: Implications of the blood pressure-lowering arm of the advance trial

Abstract

This review focuses on trials that have examined the relationship between blood pressure (BP) lowering strategies and cardiovascular and renal outcomes in subjects with type 2 diabetes. In particular, we highlight the results of the recently completed BP-arm of the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled Evaluation) study. Active therapy with perindopril and indapamide compared with placebo significantly reduced blood pressure (134.7/74.8 vs 140.4/77.0 mmHg) and the primary endpoint of the trial, a composite of major macrovascular and microvascular events. Active therapy also reduced the secondary end points of cardiovascular death and developme..