Journal article
Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans
P Spröte, AA Brakhage, MJ Hynes
Eukaryotic Cell | Published : 2009
DOI: 10.1128/EC.00374-08
Abstract
Peroxisomal localization of the third enzyme of the penicillin biosynthesis pathway of Aspergillus nidulans, acyl-coenzyme A:IPN acyltransferase (IAT), is mediated by its atypical peroxisomal targeting signal 1 (PTS1). However, mislocalization of IAT by deletion of either its PTS1 or of genes encoding proteins involved in peroxisome formation or transport does not completely abolish penicillin biosynthesis. This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Grants
Awarded by Deutsche Forschungsgemeinschaft
Funding Acknowledgements
We thank Sandra Murray for excellent research assistance. This work was supported by the Australian Research Council, a DAAD scholarship for Ph. D. students granted to P. S., and the Deutsche Forschungsgemeinschaft (Priority Program SPP1152).